Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway
Identifieur interne : 000151 ( Main/Exploration ); précédent : 000150; suivant : 000152Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway
Auteurs : Joshua H. K. Tam ; M. Rebecca Cobb ; Claudia Seah ; Stephen H. PasternakSource :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
The amyloid hypothesis posits that the production of β-amyloid (Aβ) aggregates leads to neurodegeneration and cognitive decline associated with AD. Aβ is produced by sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretase. While nascent APP is well known to transit to the endosomal/ lysosomal system via the cell surface, we have recently shown that APP can also traffic to lysosomes intracellularly via its interaction with AP-3. Because AP-3 interacts with cargo protein via interaction with tyrosine motifs, we mutated the three tyrosines motif in the cytoplasmic tail of APP. Here, we show that the YTSI motif interacts with AP-3, and phosphorylation of the serine in this motif disrupts the interaction and decreases APP trafficking to lysosomes. Furthermore, we show that phosphorylation at this motif can decrease the production of neurotoxic Aβ 42. This demonstrates that reducing APP trafficking to lysosomes may be a strategy to reduce Aβ 42 in Alzheimer’s disease.
Url:
DOI: 10.1371/journal.pone.0161445
PubMed: 27776132
PubMed Central: 5077117
Affiliations:
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K." last="Tam">Joshua H. K. Tam</name><affiliation><nlm:aff id="aff001"><addr-line>J. Allyn Taylor Centre for Cell Biology, Molecular Medicine Research Group, Robarts Research Institute, Western University, London Ontario, Canada, N6A 5B7</addr-line></nlm:aff><wicri:noCountry code="subfield">N6A 5B7</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff002"><addr-line>Department of Physiology and Pharmacology, Western University, London, Ontario, Canada, N6A 5B7</addr-line></nlm:aff><wicri:noCountry code="subfield">N6A 5B7</wicri:noCountry></affiliation></author><author><name sortKey="Cobb, M Rebecca" sort="Cobb, M Rebecca" uniqKey="Cobb M" first="M. Rebecca" last="Cobb">M. Rebecca Cobb</name><affiliation><nlm:aff id="aff003"><addr-line>Program in Neuroscience, Western University, London, Ontario, Canada, N6A 5B7</addr-line></nlm:aff><wicri:noCountry code="subfield">N6A 5B7</wicri:noCountry></affiliation></author><author><name sortKey="Seah, Claudia" sort="Seah, Claudia" uniqKey="Seah C" first="Claudia" last="Seah">Claudia Seah</name><affiliation><nlm:aff id="aff001"><addr-line>J. Allyn Taylor Centre for Cell Biology, Molecular Medicine Research Group, Robarts Research Institute, Western University, London Ontario, Canada, N6A 5B7</addr-line></nlm:aff><wicri:noCountry code="subfield">N6A 5B7</wicri:noCountry></affiliation></author><author><name sortKey="Pasternak, Stephen H" sort="Pasternak, Stephen H" uniqKey="Pasternak S" first="Stephen H." last="Pasternak">Stephen H. Pasternak</name><affiliation><nlm:aff id="aff001"><addr-line>J. Allyn Taylor Centre for Cell Biology, Molecular Medicine Research Group, Robarts Research Institute, Western University, London Ontario, Canada, N6A 5B7</addr-line></nlm:aff><wicri:noCountry code="subfield">N6A 5B7</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff002"><addr-line>Department of Physiology and Pharmacology, Western University, London, Ontario, Canada, N6A 5B7</addr-line></nlm:aff><wicri:noCountry code="subfield">N6A 5B7</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff003"><addr-line>Program in Neuroscience, Western University, London, Ontario, Canada, N6A 5B7</addr-line></nlm:aff><wicri:noCountry code="subfield">N6A 5B7</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff004"><addr-line>Department of Clinical Neurological Sciences, The Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada, N6A 5B7</addr-line></nlm:aff><wicri:noCountry code="subfield">N6A 5B7</wicri:noCountry></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The amyloid hypothesis posits that the production of β-amyloid (Aβ) aggregates leads to neurodegeneration and cognitive decline associated with AD. Aβ is produced by sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretase. While nascent APP is well known to transit to the endosomal/ lysosomal system via the cell surface, we have recently shown that APP can also traffic to lysosomes intracellularly via its interaction with AP-3. Because AP-3 interacts with cargo protein via interaction with tyrosine motifs, we mutated the three tyrosines motif in the cytoplasmic tail of APP. Here, we show that the YTSI motif interacts with AP-3, and phosphorylation of the serine in this motif disrupts the interaction and decreases APP trafficking to lysosomes. Furthermore, we show that phosphorylation at this motif can decrease the production of neurotoxic Aβ 42. This demonstrates that reducing APP trafficking to lysosomes may be a strategy to reduce Aβ 42 in Alzheimer’s disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Greenfield, Jp" uniqKey="Greenfield J">JP Greenfield</name></author><author><name sortKey="Tsai, J" uniqKey="Tsai J">J Tsai</name></author><author><name sortKey="Gouras, Gk" uniqKey="Gouras G">GK Gouras</name></author><author><name sortKey="Hai, B" uniqKey="Hai B">B Hai</name></author><author><name sortKey="Thinakaran, G" uniqKey="Thinakaran G">G Thinakaran</name></author><author><name sortKey="Checler, F" uniqKey="Checler F">F Checler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cirrito, Jr" uniqKey="Cirrito J">JR Cirrito</name></author><author><name sortKey="Kang, J E" uniqKey="Kang J">J-E Kang</name></author><author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name></author><author><name sortKey="Stewart, Fr" uniqKey="Stewart F">FR Stewart</name></author><author><name sortKey="Verges, Dk" uniqKey="Verges D">DK Verges</name></author><author><name sortKey="Silverio, Lm" uniqKey="Silverio L">LM Silverio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petanceska, Ss" uniqKey="Petanceska S">SS Petanceska</name></author><author><name sortKey="Seeger, M" uniqKey="Seeger M">M Seeger</name></author><author><name sortKey="Checler, F" uniqKey="Checler F">F Checler</name></author><author><name sortKey="Gandy, S" uniqKey="Gandy S">S Gandy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tian, Y" uniqKey="Tian Y">Y Tian</name></author><author><name sortKey="Chang, Jc" uniqKey="Chang J">JC Chang</name></author><author><name sortKey="Fan, Ey" uniqKey="Fan E">EY Fan</name></author><author><name sortKey="Flajolet, M" uniqKey="Flajolet M">M Flajolet</name></author><author><name sortKey="Greengard, P" uniqKey="Greengard P">P Greengard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thinakaran, G" uniqKey="Thinakaran G">G Thinakaran</name></author><author><name sortKey="Koo, Eh" uniqKey="Koo E">EH Koo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, A" uniqKey="Lai A">A Lai</name></author><author><name sortKey="Sisodia, Ss" uniqKey="Sisodia S">SS Sisodia</name></author><author><name sortKey="Trowbridge, Is" uniqKey="Trowbridge I">IS Trowbridge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, A" uniqKey="Lai A">A Lai</name></author><author><name sortKey="Sisodia, Ss" uniqKey="Sisodia S">SS Sisodia</name></author><author><name sortKey="Trowbridge, Is" uniqKey="Trowbridge I">IS Trowbridge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez, Rg" uniqKey="Perez R">RG Perez</name></author><author><name sortKey="Soriano, S" uniqKey="Soriano S">S Soriano</name></author><author><name sortKey="Hayes, Jd" uniqKey="Hayes J">JD Hayes</name></author><author><name sortKey="Ostaszewski, B" uniqKey="Ostaszewski B">B Ostaszewski</name></author><author><name sortKey="Xia, W" uniqKey="Xia W">W Xia</name></author><author><name sortKey="Selkoe, Dj" uniqKey="Selkoe D">DJ Selkoe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lorenzen, A" uniqKey="Lorenzen A">A Lorenzen</name></author><author><name sortKey="Samosh, J" uniqKey="Samosh J">J Samosh</name></author><author><name sortKey="Vandewark, K" uniqKey="Vandewark K">K Vandewark</name></author><author><name sortKey="Anborgh, Ph" uniqKey="Anborgh P">PH Anborgh</name></author><author><name sortKey="Seah, C" uniqKey="Seah C">C Seah</name></author><author><name sortKey="Magalhaes, Ac" uniqKey="Magalhaes A">AC Magalhaes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, W" uniqKey="Tang W">W Tang</name></author><author><name sortKey="Tam, Jh" uniqKey="Tam J">JH Tam</name></author><author><name sortKey="Seah, C" uniqKey="Seah C">C Seah</name></author><author><name sortKey="Chiu, J" uniqKey="Chiu J">J Chiu</name></author><author><name sortKey="Tyrer, A" uniqKey="Tyrer A">A Tyrer</name></author><author><name sortKey="Cregan, Sp" uniqKey="Cregan S">SP Cregan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pasternak, Sh" uniqKey="Pasternak S">SH Pasternak</name></author><author><name sortKey="Bagshaw, Rd" uniqKey="Bagshaw R">RD Bagshaw</name></author><author><name sortKey="Guiral, M" uniqKey="Guiral M">M Guiral</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Ackerley, Ca" uniqKey="Ackerley C">CA Ackerley</name></author><author><name sortKey="Pak, Bj" uniqKey="Pak B">BJ Pak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bagshaw, Rd" uniqKey="Bagshaw R">RD Bagshaw</name></author><author><name sortKey="Pasternak, Sh" uniqKey="Pasternak S">SH Pasternak</name></author><author><name sortKey="Mahuran, Dj" uniqKey="Mahuran D">DJ Mahuran</name></author><author><name sortKey="Callahan, Jw" uniqKey="Callahan J">JW Callahan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pasternak, Sh" uniqKey="Pasternak S">SH Pasternak</name></author><author><name sortKey="Callahan, Jw" uniqKey="Callahan J">JW Callahan</name></author><author><name sortKey="Mahuran, Dj" uniqKey="Mahuran D">DJ Mahuran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caporaso, Gl" uniqKey="Caporaso G">GL Caporaso</name></author><author><name sortKey="Gandy, Se" uniqKey="Gandy S">SE Gandy</name></author><author><name sortKey="Buxbaum, Jd" uniqKey="Buxbaum J">JD Buxbaum</name></author><author><name sortKey="Greengard, P" uniqKey="Greengard P">P Greengard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haass, C" uniqKey="Haass C">C Haass</name></author><author><name sortKey="Hung, Ay" uniqKey="Hung A">AY Hung</name></author><author><name sortKey="Schlossmacher, Mg" uniqKey="Schlossmacher M">MG Schlossmacher</name></author><author><name sortKey="Teplow, Db" uniqKey="Teplow D">DB Teplow</name></author><author><name sortKey="Selkoe, Dj" uniqKey="Selkoe D">DJ Selkoe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schrader Fischer, G" uniqKey="Schrader Fischer G">G Schrader-Fischer</name></author><author><name sortKey="Paganetti, Pa" uniqKey="Paganetti P">PA Paganetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirschberg, K" uniqKey="Hirschberg K">K Hirschberg</name></author><author><name sortKey="Miller, Cm" uniqKey="Miller C">CM Miller</name></author><author><name sortKey="Ellenberg, J" uniqKey="Ellenberg J">J Ellenberg</name></author><author><name sortKey="Presley, Jf" uniqKey="Presley J">JF Presley</name></author><author><name sortKey="Siggia, Ed" uniqKey="Siggia E">ED Siggia</name></author><author><name sortKey="Phair, Rd" uniqKey="Phair R">RD Phair</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patterson, Gh" uniqKey="Patterson G">GH Patterson</name></author><author><name sortKey="Patterson, Gh" uniqKey="Patterson G">GH Patterson</name></author><author><name sortKey="Lippincott Schwartz, J" uniqKey="Lippincott Schwartz J">J Lippincott-Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patterson, Gh" uniqKey="Patterson G">GH Patterson</name></author><author><name sortKey="Lippincott Schwartz, J" uniqKey="Lippincott Schwartz J">J Lippincott-Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tam, Jh" uniqKey="Tam J">JH Tam</name></author><author><name sortKey="Seah, C" 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Icking</name></author><author><name sortKey="Amaddii, M" uniqKey="Amaddii M">M Amaddii</name></author><author><name sortKey="Ruonala, M" uniqKey="Ruonala M">M Ruonala</name></author><author><name sortKey="Honing, S" uniqKey="Honing S">S Höning</name></author><author><name sortKey="Tikkanen, R" uniqKey="Tikkanen R">R Tikkanen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schneider, A" uniqKey="Schneider A">A Schneider</name></author><author><name sortKey="Rajendran, L" uniqKey="Rajendran L">L Rajendran</name></author><author><name sortKey="Honsho, M" uniqKey="Honsho M">M Honsho</name></author><author><name sortKey="Gralle, M" uniqKey="Gralle M">M Gralle</name></author><author><name sortKey="Donnert, G" uniqKey="Donnert G">G Donnert</name></author><author><name sortKey="Wouters, F" uniqKey="Wouters F">F Wouters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davis, Cg" uniqKey="Davis C">CG Davis</name></author><author><name sortKey="Lehrman, Ma" uniqKey="Lehrman M">MA Lehrman</name></author><author><name sortKey="Russell, Dw" uniqKey="Russell D">DW Russell</name></author><author><name sortKey="Anderson, Rg" uniqKey="Anderson R">RG Anderson</name></author><author><name sortKey="Brown, Ms" uniqKey="Brown M">MS Brown</name></author><author><name sortKey="Goldstein, Jl" uniqKey="Goldstein J">JL Goldstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Wj" uniqKey="Chen W">WJ Chen</name></author><author><name sortKey="Goldstein, Jl" uniqKey="Goldstein J">JL Goldstein</name></author><author><name sortKey="Brown, Ms" uniqKey="Brown M">MS Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T Suzuki</name></author><author><name sortKey="Nairn, Ac" uniqKey="Nairn A">AC Nairn</name></author><author><name sortKey="Gandy, Se" uniqKey="Gandy S">SE Gandy</name></author><author><name sortKey="Greengard, P" uniqKey="Greengard P">P Greengard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gandy, S" uniqKey="Gandy S">S Gandy</name></author><author><name sortKey="Czernik, Aj" uniqKey="Czernik A">AJ Czernik</name></author><author><name sortKey="Greengard, P" uniqKey="Greengard P">P Greengard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pedersen, Wa" uniqKey="Pedersen W">WA Pedersen</name></author><author><name sortKey="Kloczewiak, Ma" uniqKey="Kloczewiak M">MA Kloczewiak</name></author><author><name sortKey="Blusztajn, Jk" uniqKey="Blusztajn J">JK Blusztajn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hammond, Dn" uniqKey="Hammond D">DN Hammond</name></author><author><name sortKey="Wainer, Bh" uniqKey="Wainer B">BH Wainer</name></author><author><name sortKey="Tonsgard, Jh" uniqKey="Tonsgard J">JH Tonsgard</name></author><author><name sortKey="Heller, A" uniqKey="Heller A">A Heller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le, Wd" uniqKey="Le W">WD Le</name></author><author><name sortKey="Xie, Wj" uniqKey="Xie W">WJ Xie</name></author><author><name sortKey="Kong, R" uniqKey="Kong R">R Kong</name></author><author><name sortKey="Appel, Sh" uniqKey="Appel S">SH Appel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tam, Jh" uniqKey="Tam J">JH Tam</name></author><author><name sortKey="Pasternak, Sh" uniqKey="Pasternak S">SH Pasternak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, A" uniqKey="Lai A">A Lai</name></author><author><name sortKey="Gibson, A" uniqKey="Gibson A">A Gibson</name></author><author><name sortKey="Hopkins, Cr" uniqKey="Hopkins C">CR Hopkins</name></author><author><name sortKey="Trowbridge, Is" uniqKey="Trowbridge I">IS Trowbridge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cai, J" uniqKey="Cai J">J Cai</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name></author><author><name sortKey="Ruan, Q" uniqKey="Ruan Q">Q Ruan</name></author><author><name sortKey="Han, S" uniqKey="Han S">S Han</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author><author><name sortKey="Qi, X" uniqKey="Qi X">X Qi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenberg, Ji" uniqKey="Greenberg J">JI Greenberg</name></author><author><name sortKey="Shields, Dj" uniqKey="Shields D">DJ Shields</name></author><author><name sortKey="Barillas, Sg" uniqKey="Barillas S">SG Barillas</name></author><author><name sortKey="Acevedo, Lm" uniqKey="Acevedo L">LM Acevedo</name></author><author><name sortKey="Murphy, E" uniqKey="Murphy E">E Murphy</name></author><author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gajadhar, A" uniqKey="Gajadhar A">A Gajadhar</name></author><author><name sortKey="Guha, A" uniqKey="Guha A">A Guha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee M, S" uniqKey="Lee M S">S Lee M-</name></author><author><name sortKey="Kao S, C" uniqKey="Kao S C">C Kao S-</name></author><author><name sortKey="Lemere, Ca" uniqKey="Lemere C">CA Lemere</name></author><author><name sortKey="Xia, W" uniqKey="Xia W">W Xia</name></author><author><name sortKey="Tseng H, C" uniqKey="Tseng H C">C Tseng H-</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vieira, Si" uniqKey="Vieira S">SI Vieira</name></author><author><name sortKey="Rebelo, S" uniqKey="Rebelo S">S Rebelo</name></author><author><name sortKey="Esselmann, H" uniqKey="Esselmann H">H Esselmann</name></author><author><name sortKey="Wiltfang, J" uniqKey="Wiltfang J">J Wiltfang</name></author><author><name sortKey="Lah, J" uniqKey="Lah J">J Lah</name></author><author><name sortKey="Lane, R" uniqKey="Lane R">R Lane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vieira, Si" uniqKey="Vieira S">SI Vieira</name></author><author><name sortKey="Rebelo, S" uniqKey="Rebelo S">S Rebelo</name></author><author><name sortKey="Domingues, Sc" uniqKey="Domingues S">SC Domingues</name></author><author><name sortKey="Cruz E Silva, Ef" uniqKey="Cruz E Silva E">EF Cruz e Silva</name></author><author><name sortKey="Cruz E Silva, Oab" uniqKey="Cruz E Silva O">OAB Cruz e Silva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skovronsky, Dm" uniqKey="Skovronsky D">DM Skovronsky</name></author><author><name sortKey="Moore, Db" uniqKey="Moore D">DB Moore</name></author><author><name sortKey="Milla, Me" uniqKey="Milla M">ME Milla</name></author><author><name sortKey="Doms, Rw" uniqKey="Doms R">RW Doms</name></author><author><name sortKey="Lee, Vm" uniqKey="Lee V">VM Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lammich, S" uniqKey="Lammich S">S Lammich</name></author><author><name sortKey="Kojro, E" uniqKey="Kojro E">E Kojro</name></author><author><name sortKey="Postina, R" uniqKey="Postina R">R Postina</name></author><author><name sortKey="Gilbert, S" uniqKey="Gilbert S">S Gilbert</name></author><author><name sortKey="Pfeiffer, R" uniqKey="Pfeiffer R">R Pfeiffer</name></author><author><name sortKey="Jasionowski, M" uniqKey="Jasionowski M">M Jasionowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benussi, L" uniqKey="Benussi L">L Benussi</name></author><author><name sortKey="Govoni, S" uniqKey="Govoni S">S Govoni</name></author><author><name sortKey="Gasparini, L" uniqKey="Gasparini L">L Gasparini</name></author><author><name sortKey="Binetti, G" uniqKey="Binetti G">G Binetti</name></author><author><name sortKey="Trabucchi, M" uniqKey="Trabucchi M">M Trabucchi</name></author><author><name sortKey="Bianchetti, A" uniqKey="Bianchetti A">A Bianchetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kinouchi, T" uniqKey="Kinouchi T">T Kinouchi</name></author><author><name sortKey="Sorimachi, H" uniqKey="Sorimachi H">H Sorimachi</name></author><author><name sortKey="Maruyama, K" uniqKey="Maruyama K">K Maruyama</name></author><author><name sortKey="Mizuno, K" uniqKey="Mizuno K">K Mizuno</name></author><author><name sortKey="Ohno, S" uniqKey="Ohno S">S Ohno</name></author><author><name sortKey="Ishiura, S" uniqKey="Ishiura S">S Ishiura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hongpaisan, J" uniqKey="Hongpaisan J">J Hongpaisan</name></author><author><name sortKey="Sun, M K" uniqKey="Sun M">M-K Sun</name></author><author><name sortKey="Alkon, Dl" uniqKey="Alkon D">DL Alkon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeon, Sw" uniqKey="Yeon S">SW Yeon</name></author><author><name sortKey="Jung, Mw" uniqKey="Jung M">MW Jung</name></author><author><name sortKey="Ha, Mj" uniqKey="Ha M">MJ Ha</name></author><author><name sortKey="Kim, Su" uniqKey="Kim S">SU Kim</name></author><author><name sortKey="Huh, K" uniqKey="Huh K">K Huh</name></author><author><name sortKey="Savage, Mj" uniqKey="Savage M">MJ Savage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, Tj" uniqKey="Nelson T">TJ Nelson</name></author><author><name sortKey="Cui, C" uniqKey="Cui C">C Cui</name></author><author><name sortKey="Luo, Y" uniqKey="Luo Y">Y Luo</name></author><author><name sortKey="Alkon, Dl" uniqKey="Alkon D">DL Alkon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanno, T" uniqKey="Kanno T">T Kanno</name></author><author><name sortKey="Yamamoto, H" uniqKey="Yamamoto H">H Yamamoto</name></author><author><name sortKey="Yaguchi, T" uniqKey="Yaguchi T">T Yaguchi</name></author><author><name sortKey="Hi, R" uniqKey="Hi R">R Hi</name></author><author><name sortKey="Mukasa, T" uniqKey="Mukasa T">T Mukasa</name></author><author><name sortKey="Fujikawa, H" uniqKey="Fujikawa H">H Fujikawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poulsen, E" uniqKey="Poulsen E">E Poulsen</name></author><author><name sortKey="Larsen, A" uniqKey="Larsen A">A Larsen</name></author><author><name sortKey="Zollo, A" uniqKey="Zollo A">A Zollo</name></author><author><name sortKey="J Rgensen, A" uniqKey="J Rgensen A">A Jørgensen</name></author><author><name sortKey="Sanggaard, K" uniqKey="Sanggaard K">K Sanggaard</name></author><author><name sortKey="Enghild, J" uniqKey="Enghild J">J Enghild</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vieira, Si" uniqKey="Vieira S">SI Vieira</name></author><author><name sortKey="Rebelo, S" uniqKey="Rebelo S">S Rebelo</name></author><author><name sortKey="Esselmann, H" uniqKey="Esselmann H">H Esselmann</name></author><author><name sortKey="Wiltfang, J" uniqKey="Wiltfang J">J Wiltfang</name></author><author><name sortKey="Lah, J" uniqKey="Lah J">J Lah</name></author><author><name sortKey="Lane, R" uniqKey="Lane R">R Lane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonifacino, Js" uniqKey="Bonifacino J">JS Bonifacino</name></author><author><name sortKey="Hurley, Jh" uniqKey="Hurley J">JH Hurley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gabuzda, D" uniqKey="Gabuzda D">D Gabuzda</name></author><author><name sortKey="Busciglio, J" uniqKey="Busciglio J">J Busciglio</name></author><author><name sortKey="Yankner, Ba" uniqKey="Yankner B">BA Yankner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lanni, C" uniqKey="Lanni C">C Lanni</name></author><author><name sortKey="Mazzucchelli, M" uniqKey="Mazzucchelli M">M Mazzucchelli</name></author><author><name sortKey="Porrello, E" uniqKey="Porrello E">E Porrello</name></author><author><name sortKey="Govoni, S" uniqKey="Govoni S">S Govoni</name></author><author><name sortKey="Racchi, M" uniqKey="Racchi M">M Racchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Racchi, M" uniqKey="Racchi M">M Racchi</name></author><author><name sortKey="Mazzucchelli, M" uniqKey="Mazzucchelli M">M Mazzucchelli</name></author><author><name sortKey="Pascale, A" uniqKey="Pascale A">A Pascale</name></author><author><name sortKey="Sironi, M" uniqKey="Sironi M">M Sironi</name></author><author><name sortKey="Govoni, S" uniqKey="Govoni S">S Govoni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, Tk" uniqKey="Khan T">TK Khan</name></author><author><name sortKey="Khan, Tk" uniqKey="Khan T">TK Khan</name></author><author><name sortKey="Sen, A" uniqKey="Sen A">A Sen</name></author><author><name sortKey="Sen, A" uniqKey="Sen A">A Sen</name></author><author><name sortKey="Hongpaisan, J" uniqKey="Hongpaisan J">J Hongpaisan</name></author><author><name sortKey="Lim, Cs" uniqKey="Lim C">CS Lim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name></author><author><name sortKey="Krmar, Rt" uniqKey="Krmar R">RT Krmar</name></author><author><name sortKey="Dada, L" uniqKey="Dada L">L Dada</name></author><author><name sortKey="Efendiev, R" uniqKey="Efendiev R">R Efendiev</name></author><author><name sortKey="Leibiger, Ib" uniqKey="Leibiger I">IB Leibiger</name></author><author><name sortKey="Pedemonte, Ch" uniqKey="Pedemonte C">CH Pedemonte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lehel, C" uniqKey="Lehel C">C Lehel</name></author><author><name sortKey="Olah, Z" uniqKey="Olah Z">Z Olah</name></author><author><name sortKey="Jakab, G" uniqKey="Jakab G">G Jakab</name></author><author><name sortKey="Anderson, Wb" uniqKey="Anderson W">WB Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ivaska, J" uniqKey="Ivaska J">J Ivaska</name></author><author><name sortKey="Whelan, Rdh" uniqKey="Whelan R">RDH Whelan</name></author><author><name sortKey="Watson, R" uniqKey="Watson R">R Watson</name></author><author><name sortKey="Parker, Pj" uniqKey="Parker P">PJ Parker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ivaska, J" uniqKey="Ivaska J">J Ivaska</name></author><author><name sortKey="Vuoriluoto, K" uniqKey="Vuoriluoto K">K Vuoriluoto</name></author><author><name sortKey="Huovinen, T" uniqKey="Huovinen T">T Huovinen</name></author><author><name sortKey="Izawa, I" uniqKey="Izawa I">I Izawa</name></author><author><name sortKey="Inagaki, M" uniqKey="Inagaki M">M Inagaki</name></author><author><name sortKey="Parker, Pj" uniqKey="Parker P">PJ Parker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saraceno, C" uniqKey="Saraceno C">C Saraceno</name></author><author><name sortKey="Marcello, E" uniqKey="Marcello E">E Marcello</name></author><author><name sortKey="Di Marino, D" uniqKey="Di Marino D">D Di Marino</name></author><author><name sortKey="Borroni, B" uniqKey="Borroni B">B Borroni</name></author><author><name sortKey="Claeysen, S" uniqKey="Claeysen S">S Claeysen</name></author><author><name sortKey="Perroy, J" uniqKey="Perroy J">J Perroy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohtsu, H" uniqKey="Ohtsu H">H Ohtsu</name></author><author><name sortKey="Dempsey, Pj" uniqKey="Dempsey P">PJ Dempsey</name></author><author><name sortKey="Eguchi, S" uniqKey="Eguchi S">S Eguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lemjabbar Alaoui, H" uniqKey="Lemjabbar Alaoui H">H Lemjabbar-Alaoui</name></author><author><name sortKey="Sidhu, Ss" uniqKey="Sidhu S">SS Sidhu</name></author><author><name sortKey="Mengistab, A" uniqKey="Mengistab A">A Mengistab</name></author><author><name sortKey="Gallup, M" uniqKey="Gallup M">M Gallup</name></author><author><name sortKey="Basbaum, C" uniqKey="Basbaum C">C Basbaum</name></author><author><name sortKey="Rich, B" uniqKey="Rich B">B Rich</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cobb, M Rebecca" sort="Cobb, M Rebecca" uniqKey="Cobb M" first="M. Rebecca" last="Cobb">M. Rebecca Cobb</name><name sortKey="Pasternak, Stephen H" sort="Pasternak, Stephen H" uniqKey="Pasternak S" first="Stephen H." last="Pasternak">Stephen H. Pasternak</name><name sortKey="Seah, Claudia" sort="Seah, Claudia" uniqKey="Seah C" first="Claudia" last="Seah">Claudia Seah</name><name sortKey="Tam, Joshua H K" sort="Tam, Joshua H K" uniqKey="Tam J" first="Joshua H. K." last="Tam">Joshua H. K. Tam</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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